Well, all of the questions about why you might want to do this aside...
DEF is mostly water. The SCR emissions system is almost entirely high grade stainless steel. Urea is corrosive. If you remove the urea from the DEF -- that is, if you run water through the injectors instead -- it probably won't hurt anything, since you're reducing the level and quantity of corrosive reactants inside the stainless steel SCR system. Since that reaction is exothermic -- SCR systems get hot -- you'll also reduce physical wear and tear on the system from thermal cycling. You might also build up crud inside the reaction chamber different from the crud it's designed to handle. I'm not sure about that.
That having been said, you're also removing the catalyst from the Selective Catalytic Reduction emissions system, which means you'll get no reactions inside the chamber, and no subsequent reduction of NOx.
If you run out of DEF entirely your truck will fall into limp home mode because it knows there's nothing running through the injectors.
I really doubt that the system pre-tests for a urea solute in the DEF injectors. However, the system absolutely tests for NOx reduction after the reaction chamber. The whole point of SCR is near-zero NOx emissions from a diesel.... so you know those sensors are going to be picky. If they pick up LOADS of NOx, you're going to throw really big emissions codes. I don't know if that will throw you into limp mode or not.
We also know that the DEF system is finicky. Overfill it... let it get too low... and member trucks have gone into limp home mode. That means a dealer visit.
So... it seems like a hugely negative set of outcomes for... let me estimate... a less than 2% reduction in fuel costs?