I don't know how different it is for the 2010-2012 Cummins, but four years ago I basically did a cheap delete on my 2007 using a exhaust delete pipe, EGR block off, and sims from H&S Performance. For two years I dealt with a code and chime every time I started the engine, and then in 2012 I used a Smarty Jr to reprogram to the +40hp ME tune.
I track every tank of fuel on an Excel spreadsheet since I bought this truck new. Prior to the deletes in 2010 I averaged about 16 MPG. With the deletes it's about 18 MPG, and little to no difference in MPG since I reprogrammed with the Smarty.