Generally, it seems that people who work their trucks on a regular basis get better life out of the engine. The injectors do better when they have a load behind them from time to time and can get the temps up enough to burn off the carbon buildup. The u-joints, driveshafts, steering components, suspension components, etc. are really just wear items that will need regular maintenance/replacement. There are upgrades available that can help out a lot but if you keep your truck running then they will need attention. Injectors are also a wear item that usually don’t last more than 150k miles. Some have gotten more and some less. You can look into running ATF and 2-stroke oil in the fuel. Some have had good results and others swear it’s terrible. You can check into it and decide for yourself.