Engine shutters

Seem right around 20% throttle cruising on highway I notice this the most. The engine will shutter, like if you were to quickly press and release the peddle fast and make the truck jerk. After some reading I was thinking this may be my peddle having a bad spot (being electronic) put a new one on tonight but have the same problem. This issue started after I put in new injectors (BBI 1.5). I had some FRP issue's after the upgrade and went with the Fleece 10mm pump and PPEI tunning. Tonight I noticed that while using cruise control it is worse. Holding speed at 70 MPH or right around 2100-2300 RPM's it will get bad. If I press the pedal it will clear up and come back after a bit more cruising. Also, if I come off the highway after some heavy pedal and come to an idle the truck will start beeping (10 times) and turn on the dash grid heater light, and it kills power to below a stock tune. This code is P1222, I can clear this using the edge but will come back over time. I pulled the valve cover and was going to start pulling everything off and check for any problems tonight but figured I would ask here. Any clue what could be causing this?

*I should add, idle, running through the gears it runs fine. It's just around the 2100-2300 RMP's. When cruise control is used the Edge will show 0% APP, should of caught this prior to purchasing a new pedal.