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Your engine bay is the big issue. A 4BT from crank center line to top of valve covers is 24". That doesn't include a high mount turbo eather. But I think the 4BT was avaible with a low mount manifold. Just finding a CPL # for that app might be a problem. With a low mount the other issue might be the width of the package. With the engine centered in the chassis. The turbo would be real close to the engine cover. It would need lots of insulation or a very good heat shield.
If you keep the HP under 200 or so the E4OD or the 400 would work. The E4OD would need some type of controller. I don't know what is on the market for them. The 400 turbo is a stand alone trans. But it doesn't have an OD. So you would need a high set of rear gears for any road speed. The ally 1000 can be used also. In stock form the ally will handle even a turned up 4BT. You can get it in 5 or 6 speeds. The 5 spd is a single OD. The 6 spd has two OD's. The stock ally TCM can be reprogramed to work from a TPS signal. So that puts it into a stand alone class.
Your saying E350. Is this a box type truck or an actual Van.??? On eather one the engine bay size is about the same. What year model?
Can this swap be done. The biggest issue I see is the height of the 4BT. Engine covers can be reworked or MFG'd. But the windshield bottom edge is one place you can't modify without great expense. The windshield bottom edge is about even with the top of the engine covers on an E series. A body lift could overcome some of that issue.
If you noticed I didn't mention distance from the crank centerline downward. There are several different configurations on oil pans. So any number I could throw out might not mean anything if the oil pan is different.
2014/93 W350 DRW, fuel pin turned, 6X.018" injectors, 4" exhaust, 3" air intake horn, Super HX40/16, G56 SBC Con-OFE, 3:07's axles, 2" skyjacker lift, air ride rear suspension,B&W flatbed