two things that help me out the most mileage wise is my NV5600, and 4.10's in the axels. if I had 3.73's I would notice a larger hit in performance.
yes, a little more throttle to get her up to speed, more brake to stop her, however I can just adjust the torque management on my smarty to help out
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04.5 6spd QC 4x4 4.10's line-x on the rockers, TST, smarty
10/20/07 425hp 798tq still on the stock clutch, how much longer will she last

Many Thanks to David and the guy's at James O'neal Dodge, you guy's ROCK!!!