Be careful here. I'm not sure on a DRB or Starscan (dodge scan tool), but with a snap-on, or other "generic" passthrough reprogrammer, lots of chrysler pcm's are locked to a vin. Once programmed to a vehicle, thats it, no more. All you can do is reflash for updates, but has to remain with that vehicle. Dodge might be able to reset them, but I would make sure on your particular year model before you purchase the computer.
But to answer your question. IF they can reset the vin, then yes it will have to be reflashed to work on your truck